Lipase enzymes function to break down fatty substances in food to be more easily digested and absorbed by the body. This enzyme is generally produced when the body gets fat intake. However, sometimes the body can not make enough lipase enzymes, causing digestive disorders.
Lipase enzyme is a type of digestive enzyme. Most lipase enzymes are produced in the pancreas, but these enzymes are also produced in other organs, such as the stomach and liver. Lipase is also produced in the mouth, fat tissue, and blood vessel walls.
The lipase enzyme is responsible for breaking down fats and triglycerides into smaller molecules, namely fatty acids and glycerol. This enzyme also plays a role in helping the work of several cholesterol-lowering drugs.
Diseases That Cause Lipase Enzyme Deficiencies
Normal lipase enzyme levels in the adult body range from 0-160 U / L. Under normal conditions, the lipase enzyme will be produced in sufficient quantities to digest fat. But when the pancreas is damaged or disrupted, the amount of the lipase enzyme produced may be less or even excessive.
There are several diseases that can cause a deficiency of the lipase enzyme in the body, namely:
Crohn's disease
Crohn's disease is a type of inflammatory bowel disease. The exact cause of this disease is not yet known, but is thought to be related to heredity, unhealthy eating patterns, severe stress, to disorders of the immune system.
This disease can cause symptoms such as fatigue, weight loss, severe diarrhea, abdominal pain, bloody bowel movements, to malnutrition.
Cystic fibrosis
This disease causes mucus in the body to become thick and sticky. The mucus can make the pancreatic duct blocked, thus preventing digestive enzymes from moving to the intestine. As a result, the body becomes difficult to absorb nutrients from food.
Symptoms that arise in this disease vary, depending on which organ is affected. If it attacks the digestive tract, cystic fibrosis can cause symptoms such as chronic diarrhea, malnutrition, oily faeces, abdominal pain, until the weight continues to decrease.
Celiac disease
This disease causes interference with the immune system, so that sufferers can not consume gluten. Gluten is a protein found in grains, such as wheat and barley.
When sufferers of celiac disease consume food or drinks that contain gluten, then the immune system will overreact. This will then cause inflammation and damage in the damaged digestive tract.
Patients with celiac disease will experience several symptoms, such as diarrhea, abdominal pain, bloating, muscle aches, weakness, or constipation, after consuming gluten.
Sufficient Lipase Enzyme Needs
If your body cannot produce enough lipase or other digestive enzymes, your doctor will prescribe an enzyme supplement to replace the deficient enzyme.
Although generally quite safe to consume, lipase enzyme supplements can cause side effects, such as diarrhea, stomach cramps, and nausea. This supplement is not recommended for drinking by pregnant women and nursing mothers.
The use of lipase enzyme supplements in high doses needs to be monitored, because it can worsen the symptoms of cystic fibrosis. Lipase supplements can also have a drug interaction effect if taken together with orlistat.
To find out whether the amount of the lipase enzyme in the body is sufficient, an examination by a doctor is needed. The doctor will do a physical examination and blood test to measure the levels of the lipase enzyme and other digestive enzymes.
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